NASDAQ® NeuroInsights® Neurotech Index Components

The Index includes companies researching, developing, manufacturing, and marketing pharmaceuticals, biologics, medical devices and diagnostics for the brain and nervous system. Index companies are defined by NeuroInsights as significantly involved in neurotechnology and must meet rigorous market criteria including a $200 million market capitalization and a three month average daily trading volume of 100,000 shares.

Company

Symbol

Index weight (%)

1 mo

return (%)

 

3 mo

return (%)

 

 1 yr

return (%)

  Market Cap ($M)

Ave. Daily  Volume (Shares)

Last Price

52 Week Low

52 Week High

Acadia Pharmaceuticals

ACAD

2.26%

2%

10%

62%

568

244,381

15.38

6.63

17.33

Acorda Therapeutics

ACOR

2.17%

10%

21%

14%

576

204,792

20.27

14.41

26.58

Alexza Pharmaceuticals

ALXA

1.08%

-6%

-7%

0%

251

115,629

8.14

7.12

15.8

Alkermes, Inc.

ALKS

4.00%

-12%

14%

-4%

1651

1,122,757

16.20

12.81

18.78

Arena Pharmaceuticals

ARNA

3.48%

-12%

-16%

-37%

587

1,042,416

9.61

8.97

15.7

Aspect Medical Systems

ASPM

1.04%

1%

1%

-23%

267

138,940

13.69

11.84

21.35

Biogen Idec Inc.

BIIB

8.00%

12%

32%

56%

21838

5,536,714

74.44

42.86

84.75

Biovail Corporation

BVF

4.00%

15%

7%

41%

3210

693,872

20.01

15.30

26.48

Cephalon, Inc.

CEPH

8.00%

1%

-2%

5%

4930

1,151,750

73.74

64.65

84.83

Cyberonics, Inc.

CYBX

1.71%

4%

4%

-20%

390

212,877

14.5

12.95

27.55

Cypress Bioscience, Inc.

CYPB

2.11%

-1%

17%

71%

504

302,449

13.49

6.91

18.20

DURECT Corporation

DRRX

1.50%

6%

35%

25%

404

268,132

5.82

3.6

6.00

Elan Corporation, plc

ELN

8.00%

13%

27%

64%

11126

3,148,925

23.80

11.7

24.75

Endo Pharmaceuticals

ENDP

4.00%

-6%

-14%

3%

3927

1,613,634

29.30

26.68

35.85

Forest Laboratories, Inc.

FRX

8.00%

5%

-3%

-20%

12352

3,489,316

39.07

35.01

57.97

Integra LifeSciences

IART

4.00%

0%

-2%

31%

1273

206,465

48.47

36.36

52.85

Javelin Pharmaceuticals

JAV

1.10%

5%

28%

---

257

---

5.29

---

---

Medivation, Inc.

MDVN

2.06%

4%

27%

78%

581

339,298

20.89

11.01

25.06

Micrus Endovascular

MEND

1.55%

8%

-16%

47%

302

147,087

19.65

13.25

25.78

Natus Medical, Inc.

BABY

1.48%

14%

19%

9%

392

196,186

18.10

13.87

18.99

Neurocrine Biosciences

NBIX

1.61%

-8%

-9%

-20%

351

694,643

9.25

7.51

14.88

Neurogen Corporation

NRGN

0.88%

-11%

-7%

-34%

165

129,607

3.94

3.47

8.75

Northstar Neuroscience

NSTR

1.25%

19%

29%

-12%

343

218,489

13.25

9.59

15.27

Pain Therapeutics, Inc.

PTIE

1.76%

10%

22%

23%

452

211,554

10.26

7.00

11.00

Penwest Pharmaceuticals

PPCO

1.23%

-25%

-35%

-53%

194

1,246,552

8.29

7.35

18.68

Sepracor Inc.

SEPR

4.00%

0%

-2%

-47%

2955

2,651,623

27.54

22.25

63.24

Shire plc

SHPGY

8.00%

2%

2%

37%

13860

860,915

75.15

53.64

81.00

Somanetics Corporation

SMTS

1.09%

5%

11%

-9%

257

88,424

19.46

16.16

23.63

Somaxon Pharmaceuticals

SOMX

0.96%

-12%

-10%

-39%

163

77,588

8.92

8.85

18.57

Valeant Pharmaceuticals

VRX

4.00%

-6%

-7%

-22%

1338

546,304

14.55

14.19

19.15

Vanda Pharmaceuticals

VNDA

1.69%

8%

-20%

15%

399

612,696

15.00

8.95

32.00

XenoPort, Inc.

XNPT

4.00%

4%

15%

104%

1224

182,476

49.08

22.41

50.99

Source: NeuroInsights, NASDAQ, Morningstar as of 10/31/2007