Table of Contents


1: Executive Summary

The Brain Industry Revealed       
    Neuropharmaceuticals     
    Neurodevices      
    Neurodiagnostics       
Investment Risks and Opportunities

Translating Neuroscience into Neurotech      
The Neurotech Market Opportunity       
NASDAQ NeuroInsights Neurotech Index      
Neurotechnology and Society      
Key Industry Facts and Findings     
    Market Overview       
    Industry Overview       
    Venture Financing      
    Public Market Activity      
    Global Growth Drivers      
    Other Findings       
A Brief History of the Science Behind Neurotechnology


2: Trends and Drivers

Converging Technology Drivers       
    Stem Cells and Neuroregeneration       
    Neuroimaging, Diagnostics and Disease Treatment       
    Crossing the Blood Brain Barrier      
Demographic Drivers       
    More People Living Longer      
Social Drivers      
    The Lifestyle Improvement Market       
    Medical Tourism      
Economic Drivers       
    Global Economic Burden of Brain-Related Illness       
    Rising Health Care Costs       
Research Funding        
    US Government Research Funding        
    Stem Cell Funding       
    International Government Research Funding       
    Foundations Focus on the Brain       
Regulatory Trends      
    World Regulatory Agencies      
    Global Clinical Trials       
Intellectual Property Trends      
    Global Intellectual Property Protection       
    Patent Expirations      
    Patent Activity in the United States       


3: Neuropharmaceutical Sector

Neuropharmaceutical Sector Overview      
    Trends in Neuropharmaceuticals        
    Spotlight on Big Pharma      
    Neuropharmaceutical Partnering and Licensing       
Neurology Markets and Pipelines        
    Alzheimer’s Disease (AD)       
    AAMI and MCI       
    Epilepsy and Seizure Disorders       
    Migraine       
    Multiple Sclerosis       
    Parkinson’s Disease       
    Sleep Disorders       
         Restless Legs Syndrome       
    Stroke       
Psychiatry Markets and Pipelines       
    Addiction       
    Anxiety Disorders       
    Attention Disorders       
    Depressive Disorders       
         Bipolar Disorder        
    Obesity       
    Schizophrenia       
         Cognitive Impairment Associated with Schizophrenia       
Sensory Markets and Pipelines       
    Pain       
    Retinal Disorders

       
4: Stem Cells and Neuroregeneration

Defining Stem Cell Markets and Players       
    Therapeutics       
    Drug Discovery Tools       
    Stem Cell Banking       
Stem Cell Approaches       
    Background       
    The Science of Transplantion       
    Controlling Immune Rejection and Infection       
    Sources and Harvesting of Stem Cells       
         Embronic Stem Cells      
        Fetal Stem Cells       
        Adult Stem Cells      
        Stimulation of Endogenous Stem Cells       
    Stem Cells Scientific Hurdles      
Markets and Treatments in Development       
    Alzheimer’s Disease        
    Amyotrophic Lateral Sclerosis (ALS)      
    Hearing Loss      
    Huntington’s Disease (HD)    
    Multiple Sclerosis (MS)      
    Parkinson’s Disease      
    Retinal Disorders       
    Spinal Cord Injury (SCI)      
    Stroke       
    Other CNS Diseases      


5: Neurodevice Sector

Neurodevice Sector Overview       
    Neurodevice Markets      
    FDA Classification and Approval Process      
    Neurodevice Sector Trends       
Neuroprosthetic Devices      
    Cochlear Implants       
    Retinal Implants       
    Motor Prostheses and Brain Computer Interfaces      

Neuromodulation Devices       
    Neuromodulation Device Clinial Trials and Recent Approvals       
    Deep Brain Stimulation      
         Essential Tremor       
         Parkinson’s Disease       
         Primary Dystonia       
         Severe Obsessive Compulsive Disorder       
         Treatment-Resistant Depression       
         Epilepsy       
         Traumatic Brain Injury and Stroke       
    Transcranial Magnetic Stimulation (TMS)       
         Treatment Resistant Depression       
         Migraine       
    Spinal Cord Stimulation (SCS)       
         Chronic and Neuropathic Pain       
         Spinal Cord Injury       
    Vagus Nerve Stimulation (VNS)       
         Epilepsy      
         Treatment-Resistant Depression       
         Obesity       
    Peripheral Stimulation       
         Balance      
         Drug Delivery       
         Fecal Incontinence       
         Foot Drop       
         Hypertension       
         Migraine       
         Neuropathic Pain       
         Restless Legs Syndrome       
         Sleep Apnea       
         Stroke       
         Urinary Conditions       
         Gastric Modulation and Obesity       
Neurosurgical devices       
    Radiosurgical Devices       
    Neurosurgical Navigation and Equipment       
         Image Guided Navigation (IGN)      
         Intraoperative Magnetic Resonance Imaging (iMRI)      
         Automated Surgical Systems       
         Brain Monitoring       
         Temperature Control Systems       
    Neurovascular Intervention        
         Ischemic Stroke       
         Hemorrhagic Stroke      
Neurosoftware      
    Attention Deficit Disorder      
    Cognition and Aging       
    Emotional Wellbeing       
    Learning Disabilities and Autism       
    Pain         



6: Neurodiagnostics Sector

Neurodiagnostic Sector Overview       
    FDA Approval and Insurance Reimbursement of Diagnostics       
    Medical Divisions of Fortune 500 Companies       
Neuroimaging Technologies       
    Computed Tomography (CT)       
    Magnetic Resonance Imaging (MRI)       
    Nuclear Medicine Imaging (PET, SPECT)       
    Electro-encephalography (EEG)       
    Magneto-encephalography (MEG)       
In Vitro Diagnostics       
    In Vitro Diagnostics Regulatory Landscape       
    Emerging Diagnostics for Alzheimer’s Disease       
    Genetic Testing and Pharmacogenomics      
    Protein Biomarker Assays       
    Pattern Recognition in Diagnostics       
    Emerging Diagnostics for Psychiatry       
Neuroinformatics       
    Diagnostic Software        


7: Private Neurotechnology Investment

Private Investment in Neurotechnology       
    Venture Capital Investment Trends       
    Neurotech Venture Capital Investment       
         Investing in Neuropharmaceuticals       
         Investing in Stem Cells and Neuroregeneration      
         Investing in Neurodevices       
         Investing in Neurodiagnostics       
         Private Company Financings, 2008      
Leading Neurotech Venture Capital Firms       

8: Public Neurotechnology Investment

Investing in Public Neurotech Companies       
    Neurotech Stock Universe       
Neurotech Initial Public Offerings       
Neurotech M&A Activity      
NASDAQ NeuroInsights Neurotech Index       

9: Neurotechnology Research Centers

Leading Neurotechnology Research Centers       
    University of California, San Francisco (UCSF)       
    University of California, Los Angeles (UCLA)       
    University of California, San Diego (UCSD)       
    Harvard       
    Stanford University       
    Massachusetts Institute of Technology (MIT)       
    Columbia University       
    Washington University, St. Louis       
    University College London (UCL)       
    Karolinska Institutet, Stockholm       
    RIKEN Brain Science Institute, Japan       
Places to Watch       
    National Brain Research Centre (NBRC), India       
    Neurosciences Victoria, Australia (NSV)       
    Shanghai Institute of Brain Functional Genomics (SBG), China

     
10: Leading Neurotechnology Regions

The Global Neurotech Economy       
Nexus Ranking and Methodology       
Established Neurotech Nexus’       
Emerging Neurotech Nexus’       
Nascent Neurotech Nexus’       
Conclusions and Policy Recommendations       


11: Company Profiles

Neuropharmaceutical Companies: Private       
Neuropharmaceutical Companies: Public      
Neurodevice Companies: Private       
Neurodevice Companies: Public       
Neurodiagnostic Companies: Private       
Neurodiagnostic Companies: Public     


12: Index


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